摘要
目的：本研究分析了3162张CBCT图像，以探索腭中缝（MPS）成熟分期中的年龄和性别特征，并确定MPS骨化的统计学显著年龄阈值。方法：根据Angelieri标准将3162名参与者（1690名女性，1472名男性，年龄3-90岁）的轴向CBCT切片分为六个MPS成熟阶段（A、B、C、D1、D2、E）。Youden指数定义了MPS成熟的诊断年龄阈值；卡方检验评估了年龄、性别与阶段之间的相关性。Kolmogorov-Smirnov检验、t检验和Wilcoxon检验分析了亚组数据分布的相似性，统计显著性设定为p < 0.05。结果：区分MPS阶段A、B、C和D的最佳年龄阈值为11.2岁（男性：11.2岁，女性：10.75岁），具有较高的诊断敏感性和特异性。年龄与MPS成熟显著相关（p < 2.2e-16）。D2阶段在形态上介于D1和E之间但 distinct，其年龄分布与两者均有显著差异（p < 0.05），值得单独分期。青少年（0-20岁）显示出显著的性别差异（p < 0.05），女性成熟较早。结论：关键的MPS骨化年龄阈值为11.2岁，支持减少年轻患者的不必要放射学检查。MPS成熟随年龄进展，且在女性中较早，特别是在0-20岁期间。
原文摘要
OBJECTIVE: This study analyzed 3162 CBCT images to explore age and gender features in midpalatal suture (MPS) maturation staging, and identify the statistically significant age threshold for MPS ossification.
METHODS: Axial CBCT sections of 3162 participants (1690 females, 1472 males, aged 3-90 years) were classified into six MPS maturation stages (A, B, C, D1, D2, E) based on Angelieri's criteria. The Youden index defined the diagnostic age threshold for MPS maturation; chi-squared tests assessed correlations between age, gender and stages. Kolmogorov-Smirnov, t-test and Wilcoxon test analyzed subgroup data distribution similarity, with statistical significance set at p < 0.05.
RESULTS: The optimal age threshold for distinguishing MPS stages A, B, C and D was 11.2 years (males:11.2 years, females:10.75 years), with high diagnostic sensitivity and specificity. Age correlated significantly with MPS maturation (p < 2.2e-16). D2 stage, morphologically intermediate between D1 and E yet distinct, had a significantly different age distribution from both (p < 0.05), warranting independent staging. Adolescents (0-20 years) showed significant gender differences (p < 0.05), with females maturing earlier.
CONCLUSION: The critical MPS ossification age threshold is 11.2 years, supporting reduced unnecessary radiological examinations in younger patients. MPS maturation advances with age and is earlier in females, especially in 0-20 years.
出处
Clinical oral investigations 2026;30(9). DOI: 10.1007/s00784-026-07093-2.
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